Why Prohydrolase is important for your body?

Prohydrolase is an enzyme that comes from the pancreas. Pancreatic enzymes are necessary for the digestion of proteins and lipids and involve in maintaining pancreatic secretions. The main function of prohydrolases is to break down large protein molecules into smaller peptide chains. This gives the body access to nutrients from larger proteins that have a greater surface area. Prohydrolase is known as an endoprotease since it cuts at the interior of protein instead of the terminal end that other enzymes like carboxypeptidase and aminopeptidase attack.

How is prohydrolase made?

The prohydrolase is made in the pancreas through the action of prolyl hydroxylase, which converts proline to aspartate. The amino acid aspartate is converted to oxaloacetate, which then undergoes transamination or deamination. Oxaloacetate combines with glycine and is hydrolyzed by the enzyme pyruvate carboxylase to form malic acid. Lactic acid can reach a pH of 6 but cannot go any further because it is a weak acid that cannot disassociate further. The pH of the lactic acid remains at 6 until it combines with pyruvate and bubbles into the pancreatic ducts. These acids help in stimulating muscular contraction which helps indigestion.

How does prohydrolase help the body’s digestive process?

The alpha, beta, and gamma chains of prohydrolase are made up of different protein subunits. Proteins consist of amino acids linked together in a sequence using peptide bonds. These amino acids are joined by a covalent bond that is either an amide or ester bond. The alpha chain has the most diverse reactions. It comprises the endoproteases which break proteins down into polypeptides. The beta chain contains two reactive sites that catalyze peptidolysis with water and carboxypeptidase B to dissolve protein substrates when there is an acidic environment such as in the stomach. The gamma chain controls how much enzyme is released by regulating how long it takes for the prohydrolase to reach the stomach, browse around this site.

How do prohydrolases differ from other proteolytic enzymes?

Prohydrolases are also known as endoprotease since they cut at the interior of protein instead of the terminal end that other enzymes such as carboxypeptidase and aminopeptidase attack. This makes them useful in breaking large proteins into smaller ones carboxypeptidase and aminopeptidase can further break that down.

Prohydrolases are found in the pancreas, small intestine, stomach, and blood. The prohydrolase that is produced by the pancreas helps to stimulate the production and secretion of digestive enzymes by pancreatic acinar cells. The prohydrolase, which constitutes about 3% of all proteolytic enzymes, helps to digest proteins in the small intestine and stomach, as well as blood proteins such as hemoglobin.

Why does the body suffer from a lack of prohydrolase?

If the body lacks a prohydrolase enzyme, then it will be unable to break down larger proteins. Proteins have a greater surface area and can’t be used by the body if they’re not broken down into smaller peptides. This causes many problems including low production of pancreatic juice which can cause malnutrition or symptoms such as nausea, vomiting, fever, and abdominal pain.


In short, prohydrolases are crucial for digestive health and how the body works. If you’re not getting enough proteolytic enzymes, your digestion will take a lot more time to process food and you’ll feel less satisfied after eating.